The application of L-Lysine (also known as L-Lysine/Lysine) began in 1968 when research indicated that it can be used to combat cold sores caused by human herpes simplex virus (HSV-1). Even feline herpes virus infections related to felines.
However, L-Lysine is not just medicine for treating herpes because it’s also crucial in various physiological processes.
What are the benefits of L-Lysine supplements?
Table of Contents
- What is L-Lysine?
- What are the benefits of L-Lysine?
- Are there any side effects of L-Lysine?
- Safety Precautions
- The dosage of lysine (how to use)?
- What are the foods rich in L-Lysine?
- Where to buy the most recommended L-Lysine?
What is L-Lysine?
L-Lysine is one of the 9 essential amino acids required for human growth and tissue repair. It is an essential part of the protein. If it is lacking, it will cause the degradation of cell tissues and may cause serious health problems. So take it in the diet It is important to add enough amino acids.
For example, L-Lysine is involved in the production of carnitine (carnitine converts fatty acids into energy and regulates cholesterol levels) and helps your body produce hormones, enzymes, and antibodies.
What are the benefits of L-Lysine?
1. L-Lysine improves herpes simplex virus infection
Herpes simplex virus is divided into type 1 and type 2 (HSV-1 and HSV-2), which is a human neuro virus belonging to the herpesvirus family.
Its clinical manifestations vary from asymptomatic infections or mild mucosal lesions on the lips, cornea, genitals or skin to more serious and even life-threatening infections, including encephalitis and neonatal infections.
A double-blind, placebo-controlled trial (6 months, 52 patients with recurrent herpes simplex) pointed out that oral L-Lysine (1,000 mg, 3 times a day) can help reduce recurrent herpes simplex) The number of infections, the severity of symptoms and the recovery time required.
Another study, also targeting recurrent cold sores, found that supplementing 1000 mg of lysine per day for 12 months can reduce the number of lesions (in addition, the number of cold sores is related to the concentration of lysine in the blood. The incidence of cold sores in patients above 165 nmol/ml is low.
Another double-blind, placebo-controlled (12-week, 65 patients with recurrent herpes labialis) pointed out that lysine (1000 mg daily) did not help reduce the relapse rate, improve the healing rate and improve the lesion.
*Conclusion: For recurrent herpes simplex (HSV-1), supplementation with lysine may help reduce recurrence, reduce the severity and help to heal, but is limited by the small sample size and inconsistent results. More large studies are still needed to confirm its clinical benefit.
2. Does L-Lysine improve and prevent feline herpes virus infection?
Feline herpesvirus is a common infectious disease in cats. The main source of transmission is the nose, eye, and eye secretions of infected cats.
Although vaccines against these viruses have been widely used in breeding cats, infection with these viruses is still common, especially when cats are raised in groups.
Possible clinical symptoms after infection include: fever, serous ocular-nasal discharge, conjunctivitis, keratitis, sneezing, coughing, difficulty breathing, loss of appetite, drowsiness, and pneumonia and death are rare.
A systematic review pointed out that lysine did not help prevent or treat feline herpesvirus 1 infection, and some reports even found that lysine supplements increased the frequency of infection and the severity of the disease degree.
3. L-Lysine benefits schizophrenia
Schizophrenia is a serious chronic mental illness and one of the most disabling diseases in all medicines. The lifetime risk of illness is about 1%. The main pathogenic factors are related to genetic inheritance (up to 80%) and environmental factors.
Its core features include positive symptoms (delusions and hallucinations, and loss of contact with reality), negative symptoms (especially impaired motivation, reduced self-speaking, and social withdrawal) and cognitive impairment.
A single-blind, randomized, cross-over study (for 8 weeks, targeting 10 patients with schizophrenia) pointed out that the combination of high-dose L-Lysine in addition to traditional antipsychotic drugs can further improve the positive and negative symptom scale (PANSS) and Wisconsin Card Sorting Test score, the range is especially the most significant for delusions, suspicions, problem-solving skills, and cognitive flexibility.
*Conclusion: L-Lysine combined with traditional drug therapy may bring further help to schizophrenia, but it is limited by the insufficient number of samples, and more studies are needed to corroborate it.
4. L-Lysine is beneficial for blood sugar control
All types of diabetes are characterized by hyperglycemia, relative or absolute lack of insulin action, pathway-selective insulin resistance, diabetes-specific pathological development of the retina, glomeruli, and peripheral nerves.
Diabetes is also associated with atherosclerotic diseases, affecting the arteries supplying the heart, brain, and lower extremities. Clinically, more than 30% of hospitalized patients with acute myocardial infarction have diabetes, and 35% have impaired glucose tolerance.
A controlled study (subject to type 2 diabetic patients receiving medical treatment) pointed out that the use of lysine reduced the concentration of advanced glycation end products in the serum of patients compared with the control group.
Another study (targeting 13 healthy adults) pointed out that ingesting lysine can slightly lower blood sugar and increase the concentration of glucagon and insulin.
Are there any side effects of L-Lysine?
For most people, it is safe to use L-Lysine at an appropriate dose, but possible side effects or adverse reactions that have been reported include diarrhea, nausea, and abdominal pain.
There have been cases of kidney disease (Fanconi’s syndrome and tubulointerstitial nephritis) caused by long-term overdose. Symptoms of kidney disease may include pain between the buttocks and ribs, decreased urine output, nausea and vomiting, and bloody stools.
1. Do not use during pregnancy and breastfeeding (because the relevant safety is unknown).
2. Do not use it in combination with calcium tablets (because L-Lysine will increase calcium absorption, too much calcium may cause hypercalcemia).
3. Do not use it in combination with Arginine. Since lysine and arginine use the same transporter molecule, if used together, they will produce antagonistic effects and reduce the rate of mutual absorption.
4. Do not use in patients with a history of gallstones or high cholesterol (because excessive intake of lysine will increase cholesterol levels and may increase the chance of gallstone formation).
5. Do not use in patients with diseases related to Hyperlysinemia or hyperlysinuria.
6. Do not use if the liver and kidney function is poor (because the relevant safety is unknown).
7. Do not use with Aminoglycoside Antibiotics, which may affect the efficacy of the drug. The related drug names are Streptomycin, kanamycin, tobramycin, gentamicin, neomycin, Amikacin, netilmicin.
8. Do not use in combination with gastrointestinal motility drugs, which may affect the efficacy of drugs. The names of related drugs are: prucalopride, tegaserod
The dosage of lysine (how to use)?
The basic level of lysine required to maintain human health is 30 mg/kg body weight. A person who converts to 70 kg body weight needs to consume about 2.1 g (grams) of lysine daily from food.
For the prevention or treatment of herpes simplex infection, the supplemental dose of lysine is about 1 to 3 grams per day (for 6 months to 1 year)
Lysine is present in natural high-protein foods, especially meat and dairy products, and is relatively small in plant foods
Foods rich in lysine include (per 100g content):
- Pork 2757mg / 100g
- Egg 912mg / 100g
- Shrimp 2172mg / 100g
- Chicken 3110mg / 100g
- Soybean and its products (tofu, protein powder) 2634 mg / 100g
- Lean beef and lamb 3582 mg / 100g
- Tuna/Tuna 2590mg/100g
- Parmesan Cheese 3306mg / 100g
- Pumpkin seeds 1386mg / 100g
Where to buy the most recommended L-Lysine?
In recent years, food safety problems in various countries have exploded, and it is not healthy but black-hearted products that everyone spends on. Therefore, European and American products with relatively strict quality control have become popular products.
And iHerb.com is a large-scale medical cosmetics e-commerce company in the United States. It has a high satisfaction rate of 97% in the evaluation of Google customers. It provides global home delivery so that you can buy it without risking buying fakes through purchasing high-quality health products.