SAM-e (S-adenosylmethionine/s-adenosylmethionine) is a common endogenous amino acid in the human body, which is mainly synthesized by methionine and adenosine triphosphate and is indispensable for methylation, transfiguration, and aminopropylation. Nucleic acid and protein, Phospholipids, and amines are related to the formation and decomposition.
Today, the medical community has discovered that SAMe may have a clinically significant effect on osteoarthritis, chronic liver disease, and depression, and has become a popular research target.
Do you know the benefits of SAM-e supplement?
Table of Contents
- What are the benefits recommended by SAM-e?
- Are there any side effects of oral SAM-e?
- Safety precautions
- Where to buy SAM-e health food recommended by most people?
What are the benefits recommended by SAM-e?
1. Improve depression
Depression is one of the diseases that account for a large proportion of the current global disease burden. The lifetime prevalence rate is about 20%, and the male to female ratio is about 2 to 5. About 300 million people suffer from diseases. The causes are often related to genetics, chronic inflammation, Endocrine, and immune dysfunction are related.
A Cochrane Review (including 8 studies, 934 participants) pointed out whether the use of SAM-e (S-adenosylmethionine) could improve due to inconsistent results and a lack of high-quality evidence. Adult depression can not reach a rigorous conclusion.
*Conclusion: Compared with placebo or anti-depressant drugs, there is still no clear evidence that SAM-e can be used to improve depression, which needs to be confirmed by more large-scale and accurate research.
2. Improve hot flashes
Hot flashes are the most common discomfort in menopausal women (the prevalence rate is about 75%). The main symptoms are fever, accompanied by intense sweating, redness of the face and chest, palpitations, and anxiety. The duration of the attack is about 3 to 10 minutes, a few It may last for hours.
In addition, some women with breast cancer suffer from estrogen deficiency due to treatment, which can also cause hot flashes. For example, 60% to 70% of patients will experience hot flushes after using tamoxifen (an anti-estrogen drug).
A single-arm phase II trial (single-arm phase II trial, 7 weeks, for 43 women with hot flashes) pointed out that compared with the placebo control group, oral SAM-e (dose 400 mg, twice a day) failed to produce a clinically significant improvement in hot flashes, and there was no difference in the quality of life.
*Conclusion: According to the current study, there is no evidence that oral SAM-e can improve hot flashes.
3. Improve osteoarthritis
Osteoarthritis is a progressive degenerative disease, with a lifetime prevalence rate of about 45%, especially for the elderly and older. Among them, obesity is an aggravating risk factor, and the risk of disease is doubled.
In addition to articular cartilage defects, osteoarthritis may also be accompanied by subchondral bone sclerosis, bone spur formation, ligament relaxation, weakened peripheral muscles, and synovitis. Patients usually have joint pain, stiffness, and restricted movement.
A Cochrane Review (Cochrane Review, including 4 randomized controlled studies, 656 participants) pointed out that the use of SAMe (S-adenosylmethionine) to improve osteoarthritis has potential clinical relevance, but for The improvement in pain and function is minimal, coupled with the heterogeneity and bias between studies, so it is not recommended for routine treatment.
*Conclusion: Due to the lack of high-strength evidence, the improvement effect of SAMe on osteoarthritis is still not clear.
4. Improve Fibromyalgia
Fibromyalgia is a chronic generalized pain disease, which is mainly characterized by pain and fatigue in body parts (muscles, tendons, and joints). In addition, sleep/cognition/gastrointestinal dysfunction, depression, and anxiety may also occur.
As of now, the cause of fibromyalgia is still unknown, but it may be related to genetic, neurological, psychological, sleep, and immune factors.
A double-blind controlled study (6 weeks, 44 subjects with fibromyalgia) pointed out that oral SAM-e (800 mg) improved clinical disease activity, morning stiffness, pain, and emotional assessment compared to placebo The effect may be one of the treatment options.
*Conclusion: Oral SAM-e may have a positive effect on fibromyalgia, but more research is still needed to verify.
5. Beneficial liver cirrhosis
Cirrhosis is a common pathological phenomenon of the chronic liver disease progressing to the later stage (caused by hepatocellular degeneration and necrosis, tissue fibrosis and regenerative nodules), the common causes are mainly alcoholism, hepatitis B or C virus infection, and non-alcoholic fatty liver disease-related.
A randomized, double-blind controlled trial (a 2-year study of 123 patients with alcoholic cirrhosis) indicated that oral SAMe (S-adenosylmethionine) improved overall survival and reduced liver disease compared to placebo Transplantation events, especially in non-progressive liver disease subjects, are most significant.
*Conclusion: Oral SAM-e may be helpful for liver disease improvement, but more large-scale empirical confirmation is still required.
Are there any side effects of oral SAM-e?
Generally speaking, SAMe is safe to use in moderation, but the possible side effects that have been reported include nausea, vomiting, constipation, dry mouth, headache, dizziness, exhaustion, diarrhea, anxiety, restlessness, palpitations, mild insomnia, loss of appetite, Sweating, tension, etc., especially when using high doses.
Safety Precautions
Do not use when pregnant or breastfeeding (because the relevant safety is unknown).
Do not use in patients with bipolar disorder, low immune function, Parkinson’s disease, Lesch-Nyhan Syndrome-related diseases, may worsen the condition.
Do not use in combination with antidepressants or drugs that affect nerve conduction substances, it may increase the incidence of Serotonin Syndrome, and there will be restlessness, increased heart rate and high blood pressure, dilated pupils, muscle stiffness, and excessive sweating.
Do not use with hypoglycemic drugs, because SAMe may have a hypoglycemic effect and may cause hypoglycemia.
Where to buy SAM-e health food recommended by most people?
In recent years, food safety problems in various countries have exploded, and it is not healthy but black-hearted products that everyone spends on. Therefore, European and American products with relatively strict quality control have become popular products.
And iHerb.com is a large-scale medical cosmetics e-commerce company in the United States. It has a high satisfaction rate of 97% in the evaluation of Google customers. It provides global home delivery so that you can buy it without risking buying fakes through purchasing high-quality health products.
